Experiments
Replifactory can maintain continuous cultures in various modes:
chemostat
turbidostat
morbidostat
phage lagoon.
Experiment with our simulation!
Culture control parameters are described in the documentation.
Chemostat/Turbidostat: the culture is diluted at regular time intervals or when the OD reaches a threshold.
Because the pumps are shared, discrete dilutions are used instead of a slow continuous dilution, resulting in a pseudo-turbidostat regime, where the OD drops slightly at every dilution. In the figure below the culture is diluted every 3h by adding and removing 10mL of growth medium. Smaller dilution coefficients are possible, by accurately pumping volumes as low as 0.2mL.
Morbidostat: the amount of drug medium pumped in the vial can be varied throughout the experiment.
Below, the drug dose is set to 10mM, then 20mM, then 40mM, increasing stress as the culture recovers. Adjusting the stress level in response to adaptation leads to rapid evolution of resistance.
A small rearrangement of the tubing connections converts the device into a multivial “lagoon” setup for continuous phage culture.
Phage lagoon: Yellow arrows on the graph indicate when the vial is diluted. Red arrows indicate feeding of E.coli culture to the phage vial. After feeding, the E.coli culture keeps growing for about 50 minutes, then the OD rapidly drops as they lyse. After each cycle, the lagoon is first diluted with clean LB to lower the number of phages in the vial, then they are fed with fresh exponential phase E.coli.
Also try the animated version of the simulation :)